CYP2E1*5B, CYP2E1*6, CYP2E1*7B, CYP2E1*2, and CYP2E1*3 Allele Frequencies in Iranian Populations

Allele Frequencies of CYP2E1 Gene Polymorphisms in Iranian Populations

The only member of human cytochrome P450 E subfamily is CYP2E1 (Zhuge et al., 2003), located in the 10q24.3-qter region of chromosome 10. It contains 9 exons, 8 introns, and a typical TATA box and it spans 11,413 base pairs of genomic DNA (Umeno, 1988). CYP2E1 plays a key role in the metabolic activation of many low molecular weight carcinogens (e.g., benzene, N-nitrosamines, carbon tetrachlori...

CYP2E1*5B, CYP2E1*6, CYP2E1*7B, CYP2E1*2, and CYP2E1*3 allele frequencies in iranian populations.

BACKGROUND CYP2E1 encodes an enzyme which is mainly involved in bioactivation of potential carcinogens such as N-nitrosamines. Polymorphisms in the gene have been reported to be associated with cancer. The aim of this study was to evaluate genotype distributions and allele frequencies of five CYP2E1 polymorphisms in Iran. MATERIALS AND METHOD Two hundred healthy individuals of an Iranian popu...

Variation in optineurin (OPTN) allele frequencies between and within populations

PURPOSE To evaluate the extent to which mutations in the optineurin (OPTN) glaucoma gene play a role in glaucoma in different populations. METHODS Case-controlled study of OPTN sequence variants in individuals with or without glaucoma in populations of different ancestral origins and evaluate previous OPTN reports. We analyzed 314 subjects with African, Asian, Caucasian and Hispanic ancestrie...

Allele Frequencies and Genotype Frequencies

Null Allele Frequencies at HLA-G Locus in Iranian Healthy Subjects

Background: HLA-G gene contains 15 alleles including a null allele, HLA-G*0105N. Previous studies have shown that HLA-G*0105N does not encode the complete HLA-G1 or HLA-G5 isoforms but encodes a functional HLA-G protein with the ability to in-hibit NK cell cytolysis. Thus, although the biological functions of HLA-G1 and HLA-G5 proteins are abrogated, other isoforms such as HLA-G2 can replace th...